The manufacturing industry in North America is undergoing its fourth evolution into a high-technology, digitalized, and data-driven industry. This Industry 4.0 period began long before the COVID-19 pandemic affected global society but has been accelerated in response to many of the challenges associated with it. In this report, we examine and explore the current manufacturing industry in North America and the challenges and opportunities it faces as adoption of Industry 4.0 thinking, tools, standards, and processes becomes more widespread.